The widespread use of antibiotics leads to resistant strains of microorganisms and antibiotic resistance is increasing throughout the world, therefore, access to new sources of drugs with fewer side effects is important. This paper examines the effects of biological extracts of ethylacetate, methanol and methanol-water of Colpomenia sinousa and Iyengaria stellata in the Northern coast of the Persian Gulf.
In this study after sampling, antibacterial, antifungal and aniticancer effects of extracts of Colpomenia sinousa and Iyengaria stellata collected from Persian Gulf on a strain of bacteria called Staphylococcus aureus (gram-positive) and E.coli (gram-negative), Pseudomonas aeruginosa examined and the results were compared with standard antibiotics. Extraction was performed using percolation method. Antibacterial effects (MIC) of the final extracts based on a tube dilution method were determined. All three extracts, ethyl acetate, methanol and methanol-water of Colpomenia sinousa and Iyengaria stellata Showed antibacterial effects of Persian Gulf Coast and among the extracts, ethyl acetate extracts of Iyengaria stellata (MIC> 2/5 mg / ml) on each of the three strains of bacteria Staphylococcus aureus (PTCC: 1112), E coli (PTCC: 1338), Pseudomonas aeruginosa (PTCC1707) have the greatest effect.
Results of the antifungal tests showed that two algae have no antifungal activity.
The anticancer effect showed, The methanol extracts of Colpomenia sinousa at a concentration of 100 mgr/ml can destroy 59% of cancer cells after 48 hours in vitro. Ethyl acetate extract of Iyengaria stellata at a concentration of 200 mgr/ml can destroy 35% of cancer cells after 48 hours in vitro.