Background: A high prevalence of human T-cell lymphotropic virus type 1 (HTLV-I) infection in Mashhad city has been reported. In addition adult T cell leukemia and HTLV-I associated myelopathy/ tropical spastic paraparesis, this infection could be result in several autoimmune diseaeses. Studies reported an association between HTLV-I infection and some autoantibodies with important roles in autoimmune disorders.
Methods: In this study 105 HTLV positive (cases) and 104 age- and sex matched HTLV negative blood donnors (controls) were compared for serum autoimmune markers including ANA, ANCA, Anti-CCP, IgG anti phospholipid and RF using SPSS software.
Results: The mean ages of cases and controls were 40.8±9.4 and 41.5±9.3 years, respectively (p=0.5). In case group, 81.9% and in control group 83.7% were males (p=0.74). In both grous, 1.9% showed an ANA seropositivity (p=0.68). Only one sample (1%) from case group was ANCA positive and no reactive case of IgG anti-Phospholipid was observed. The prevalences of anti-ccp and RF seropositivity had no significant differences between two groups (2.9 and 1 percents, respectively, p=0.62 and 8.6 and 2.9 percents, respectively, p=0.08). In all 12 RF positive samples, RF values were higher than normal (33-37 IU/ml).
Conclusion: No difference was observed in serum autoantibodies between HTLV positive and HTLV negative individuals. Evaluation of the markers among patients with HAM/TSP and ATLL as well as the viral load are recommended.